Diastereoselective formal synthesis of a monoterpene alkaloid, (-)-incarvilline.
نویسندگان
چکیده
Diastereoselective formal synthesis of a monoterpene alkaloid, (-)-incarvilline, the key intermediate for the synthesis of (-)-incarvillateine, was achieved by using an intramolecular Pauson-Khand reaction of (S)-N-[(E)-2-butenyl]-N-(3-butynyl-2-methoxymethoxy)-p-toluenesulfonamide as a key step.
منابع مشابه
Chem. Pharm. Bull. 53(9) 1178—1179 (2005)
nese crude drug, has been used to treat rheumatism and to relieve pain. In the studies on its pharmacological active substances, seventeen novel alkaloids including incarvilline, incarvine A (2), incarvine C (3) and incarvillateine (4) were isolated and their structures were characterized. Incarvillateine (4) was found to show a more potent antinociceptive effect than morphine in the formalin t...
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ورودعنوان ژورنال:
- The Journal of organic chemistry
دوره 72 17 شماره
صفحات -
تاریخ انتشار 2007